NORMAN — A week off didn't cure Oklahoma's problems.
Jalen Hurts threw for three touchdowns, rushed for two more and Kennedy Brooks rushed for 131 yards, but OU nearly blew a 21-point second half lead.
The Sooners, ranked No. 9 in the first College Football Playoff top 25, were coming off a 48-41 loss at Kansas State two weeks ago.
OU's defense seemed to take that loss personally early, holding Iowa State to 8 yards on its first two series. But after going ahead 28-7, the Sooners could never put the Cyclones away.
Iowa State turned the ball over on downs on a fourth-and-goal play with 7:37 left in the game down 14, then cut the lead to 42-35 a series later on a 33-yard pass from Brock Purdy to Sean Shaw Jr.
The Cyclones got within one on their final series after a Hurts interception, scoring on a 13-yard pass from Purdy to Charlie Kolar with 24 seconds left, but Iowa State's two-point try was intercepted.
ESPN College GameDay will broadcast live from Waco next week, the network announced Saturday evening.
Guerin Emig: Sooners got away with one Saturday night, but for how much longer?
Motley's interception on two-point play seals Sooners victory
Click here for all our coverage from OU's game against Iowa State
First down | Story of the game
Second down | Matchup that mattered
Third down | Game MVP
Fourth down | What’s next
Iowa State at Oklahoma notebook: Mann, Sermon exit with injuries
OU vs. Iowa State stats
First down | Top storyline
Second down | Key matchup
Third down | Player to watch
Fourth down | Who wins and why
Winning comes first, but Sooners also hope November is filled with chaos
College Football Playoff: A look at the eight teams ranked higher than OU
Catching up with this week's OU coverage
The Tulsa World’s annual Outpick the Picker contest is back in 2019. Here are the specifics:
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